Safety First: Understanding the Side Effects of Aspadol

Last medically reviewed: 16 January 2026, Reviewed by: Medical professional (MD)

Living with moderate to severe pain, whether caused by surgery, injury, or chronic conditions such as arthritis or diabetic neuropathy can significantly impact your daily life. Aspadol, a prescription medication containing tapentadol, is sometimes prescribed by professionals to help manage these types of pain.

Like all opioid-based pain medications, Aspadol may cause side effects. Understanding these potential effects is essential for anyone who is considering or already using this medication. This guide explains the common and serious side effects of Aspadol, who may be at higher risk, and how to use it safely.

What Is Aspadol?

Aspadol is a prescription opioid analgesic that contains the active ingredient tapentadol. It works through a dual mechanism:

• Activating opioid receptors to reduce pain signals
• Inhibiting norepinephrine reuptake, which helps modulate pain perception

Because of this dual action, Aspadol may be prescribed for:

• Acute pain (such as post-surgical pain)
• Chronic pain (including certain nerve-related pain conditions)

Aspadol is available in immediate-release (IR) and extended-release (ER) formulations. Immediate-release tablets are generally used for short-term pain, while extended-release formulations may be prescribed for continuous pain under medical supervision.

Common Side Effects of Aspadol Tablets

Most of the people who are taking any dosage of Aspadol whether it is aspadol 100 mg for acute pain or aspadol 200 mg for chronic pain condition, will experience mild to moderate side effects, particularly during the first few days of treatment or when the dosage is adjusted. These effects often improve as the body adapts.

Commonly reported side effects include:

• Nausea or vomiting – more likely when taken on an empty stomach
• Drowsiness or sleepiness – avoid driving or operating machinery
• Dizziness or lightheadedness, especially when standing quickly
• Headache
• Constipation – common with opioid medications
• Fatigue or low energy levels
• Indigestion or mild stomach discomfort

If these effects worsen, consult your doctor. Dose adjustments or supportive treatments may help.

Serious Side Effects That Require Medical Attention

Although less common, some side effects can be serious and may require urgent medical care. Seek immediate medical help if you experience:

1. Respiratory Depression

Slow, shallow, or difficult breathing especially when Aspadol is taken in high doses or combined with alcohol or sedatives.

2. Seizures

Tapentadol may lower the seizure threshold, particularly in individuals with a history of seizures or when misused.

3. Serotonin Syndrome

A rare but dangerous condition that may occur when Aspadol is combined with other serotonergic medications. Symptoms include agitation, confusion, fever, sweating, tremors, and rapid heartbeat.

4. Low Blood Pressure (Hypotension)

Sudden drops in blood pressure can cause dizziness, fainting, or weakness.

5. Allergic Reactions

Signs include rash, itching, swelling of the face or throat, or difficulty breathing.

6. Adrenal Insufficiency

Long-term use of opioid may affect adrenal gland function, leading to fatigue, weight loss, or low blood pressure.

7. Dependence or Addiction

Aspadol carries a risk of physical dependence and misuse, even when used as prescribed.

If you notice any of these symptoms, don’t wait, immediately get medical help.

Who May Be at Higher Risk?

Certain individuals may be more sensitive to Aspadol’s effects:

• Older adults (65+)
• Pregnant or breastfeeding women
• People with liver, kidney, lung, or heart conditions
• Individuals with a history of seizures or substance misuse
• Patients taking other CNS depressants or antidepressants

Always disclose your full medical history and medication list to your doctor before starting Aspadol.

What to Do If Side Effects Persist?

If side effects do not improve or become severe, your doctor may:

• Adjust your dosage
• Recommend alternative pain treatments
• Provide supportive therapies for symptom management
• Monitor you more closely if risk factors are present
• Never change or stop your medication without medical guidance.

Tips for Using Aspadol Medication Safely

To reduce the risk of side effects and stay safe while consuming aspadol, follow these effective tips:

• Take Aspadol exactly as prescribed
• Swallow tablets whole, do not crush or chew
• Stay hydrated and consume fiber-rich foods
• Avoid alcohol and other sedatives
• Do not stop suddenly without medical advice
• Store securely and dispose of unused tablets properly
• Be alert to signs of overdose such as extreme drowsiness or slow breathing

Frequently Asked Questions

1. How soon do side effects appear?

Some may appear within hours, while others develop over several days.

2. Are side effects permanent?

Most are temporary and improve as the body adjusts.

3. Should I stop if I feel dizzy?

Contact your doctor before making any changes.

Conclusion

Aspadol can be effective for managing moderate to severe pain, but it requires careful and responsible use. Understanding its side effects, following medical advice, and monitoring your response can help reduce risks and improve safety.

If you have concerns about side effects or long-term use, consult a qualified professional doctor.

This content is for informational purposes only and does not replace professional medical advice.

References

• FDA Prescribing Information for Tapentadol
• Drugs.com Tapentadol Monograph
• WHO Opioid Safety Reviews
• Clinical pain management literature

Stay safe, stay informed!